ganoderic acid D

Modify Date: 2024-01-02 09:49:02

ganoderic acid D Structure
ganoderic acid D structure
Common Name ganoderic acid D
CAS Number 108340-60-9 Molecular Weight 514.650
Density 1.2±0.1 g/cm3 Boiling Point 688.3±55.0 °C at 760 mmHg
Molecular Formula C30H42O7 Melting Point N/A
MSDS N/A Flash Point 384.1±28.0 °C

 Use of ganoderic acid D


Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].

 Names

Name ganoderic acid D
Synonym More Synonyms

 ganoderic acid D Biological Activity

Description Ganoderic acid D, a highly oxygenated tetracyclic triterpenoid, is the major active component of Ganoderma lucidum. Ganoderic acid D upregulates the protein expression of SIRT3 and induces the deacetylated cyclophilin D (CypD) by SIRT3. Ganoderic acid D inhibits the energy reprogramming of colon cancer cells including glucose uptake, lactate production, pyruvate and acetyl-coenzyme production in colon cancer cells[1]. Ganoderic acid D can inhibit the growth of numerous cancer cell lines and it inhibits HeLa human cervical carcinoma cells with an IC50 of 17.3 mM[2].
Related Catalog
Target

SIRT3

References

[1]. Liu Z, et al. Effect of ganoderic acid D on colon cancer Warburg effect: Role of SIRT3/cyclophilin D. Eur J Pharmacol. 2018 Apr 5;824:72-77.

[2]. Yue QX,et al. Proteomics characterization of the cytotoxicity mechanism of ganoderic acid D and computer-automated estimation of the possible drug target network. Mol Cell Proteomics. 2008 May;7(5):949-61.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 688.3±55.0 °C at 760 mmHg
Molecular Formula C30H42O7
Molecular Weight 514.650
Flash Point 384.1±28.0 °C
Exact Mass 514.293030
PSA 125.81000
LogP 2.43
Vapour Pressure 0.0±4.9 mmHg at 25°C
Index of Refraction 1.559

 Synonyms

Ganoderic-acid-D
Lanost-8-en-26-oic acid, 7-hydroxy-3,11,15,23-tetraoxo-, (7β)-
GanodericacidD
(7β)-7-Hydroxy-3,11,15,23-tetraoxolanost-8-en-26-oic acid
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