Magainin 2
Magainin 2 structure
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Common Name | Magainin 2 | ||
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| CAS Number | 108433-95-0 | Molecular Weight | 2466.90000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C114H180N30O29S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of Magainin 2Magainin 2 is an antimicrobial peptide discovered in the skin of Xenopus laevis. |
| Name | Magainin II |
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| Synonym | More Synonyms |
| Description | Magainin 2 is an antimicrobial peptide discovered in the skin of Xenopus laevis. |
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| Related Catalog | |
| In Vitro | Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein[1]. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance[2]. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium, and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei[3]. |
| Cell Assay | Escherichia coli cells are incubated with magainin 2 (50 μg /mL). The cultures are acquired after incubation for 0, 2, 4, 6, and 8 h, respectively, and spread onto LB agar plates, and then the colony-forming units are counted after incubation for 24 h at 37°C. The percentage survival is determined relative to the control treatment[1]. |
| References |
| Molecular Formula | C114H180N30O29S |
|---|---|
| Molecular Weight | 2466.90000 |
| Exact Mass | 2465.33000 |
| PSA | 982.43000 |
| LogP | 4.91300 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | T+ |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Trypanosoma cruzi: synergistic cytotoxicity of multiple amphipathic anti-microbial peptides to T. cruzi and potential bacterial hosts.
Exp. Parasitol. 125(4) , 342-7, (2010) The parasite Trypanasoma cruzi is responsible for Chagas disease and its triatomine vector, Rhodnius prolixus, has a symbiotic relationship with the soil bacterium, Rhodococcus rhodnii. R. rhodnii tha... |
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Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II.
Peptides 33(2) , 197-205, (2012) Antimicrobial peptides (AMPs) are a naturally occurring component of the innate immune response of many organisms and can have activity against both Gram-negative and Gram-positive bacterial species. ... |
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Magainins as paradigm for the mode of action of pore forming polypeptides.
Biochim. Biophys. Acta 1376 , 391-400, (1998) Magainins are a class of antimicrobial peptides discovered in the skin of Xenopus laevis. The peptides kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity agains... |
| Magainin I,10-L-lysine-22-L-asparagine |
| Mag-2 |
| Magainin 2 |
| magainin 2 peptide,Xenopus |
| Z-12 Peptide |
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