Taccalonolide B

Modify Date: 2024-01-03 18:47:01

Taccalonolide B structure	Common Name	Taccalonolide B
	CAS Number	108885-69-4	Molecular Weight	660.705
	Density	1.4±0.1 g/cm3	Boiling Point	775.9±60.0 °C at 760 mmHg
	Molecular Formula	C₃₄H₄₄O₁₃	Melting Point	N/A
	MSDS	N/A	Flash Point	242.4±26.4 °C

Use of Taccalonolide B

Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2].

Name	taccalonolide B
Synonym	More Synonyms

Description	Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	microtubule[2]
References	[1]. LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675. [2]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.

Density	1.4±0.1 g/cm3
Boiling Point	775.9±60.0 °C at 760 mmHg
Molecular Formula	C₃₄H₄₄O₁₃
Molecular Weight	660.705
Flash Point	242.4±26.4 °C
Exact Mass	660.278198
PSA	195.49000
LogP	1.88
Vapour Pressure	0.0±6.0 mmHg at 25°C
Index of Refraction	1.604

Taccalonolide A

CAS#:108885-68-3

Taccalonolide B

CAS#:108885-69-4

Literature: Peng, Jiangnan; Risinger, April L.; Fest, Gary A.; Jackson, Evelyn M.; Helms, Gregory; Polin, Lisa A.; Mooberry, Susan L. Journal of Medicinal Chemistry, 2011 , vol. 54, # 17 p. 6117 - 6124

Precursor 1
CAS#:108885-68-3 Taccalonolide A
DownStream 0

1H-Oxireno[6',7']naphtho[1',2':7,8]fluoreno[2,1-b]furan-4,8-dione, 11,12,13-tris(acetyloxy)-5,5a,5b,6,6a,6b,7,8a,9,9a,10a,11,11a,11b,12,13,13a,13b-octadecahydro-5,6,7-trihydroxy-1,5,5a,11a,13a-pentamethyl-, (1S,5S,5aS,5bR,6R,6aS,6bS,7R,8aS,9aS,10aS,11R,11aR,11bS,12S,13R,13aR,13bS)-

(1S,5S,5aS,5bR,6R,6aS,6bS,7R,8aS,9aS,10aS,11R,11aR,11bS,12S,13R,13aR,13bS)-5,6,7-Trihydroxy-1,5,5a,11a,13a-pentamethyl-4,8-dioxo-4,5,5a,5b,6,6a,6b,7,8,8a,9,9a,10a,11,11a,11b,12,13,13a,13b-icosahydro-1H-oxireno[6',7']naphtho[1',2':7,8]fluoreno[2,1-b]furan-11,12,13-triyl triacetate