gamma-secretase modulator 2

Modify Date: 2024-01-03 18:09:18

gamma-secretase modulator 2 structure	Common Name	gamma-secretase modulator 2
	CAS Number	1093978-89-2	Molecular Weight	514.47500
	Density	1.43 g/cm3	Boiling Point	729.8ºC at 760 mmHg
	Molecular Formula	C₂₅H₂₂F₄N₆O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	395.2ºC

Use of gamma-secretase modulator 2

gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.

Name	6-fluoro-3-[4-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]triazol-1-yl]-1-(2,2,2-trifluoroethyl)-4,5-dihydro-3H-1-benzazepin-2-one
Synonym	More Synonyms

Description	gamma-secretase modulator 2 is a potent and selective γ-secretase modulator for treatment of Alzheimer's diseaseIC50 value: Target: γ-secretaseγ-secretase modulator is modulation of the action of γ-secretase so as to Selectively attenuate production of Aβ(1-42) and hence find use in treatment or prevention of diseases associated with deposition of Aβ in the brain. γ-secretase modulator is usful in particular Alzheimer's disease.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> γ-secretase Signaling Pathways >> Stem Cell/Wnt >> γ-secretase Research Areas >> Neurological Disease

Description

Related Catalog

Signaling Pathways >> Neuronal Signaling >> γ-secretase

Signaling Pathways >> Stem Cell/Wnt >> γ-secretase

Research Areas >> Neurological Disease

Density	1.43 g/cm3
Boiling Point	729.8ºC at 760 mmHg
Molecular Formula	C₂₅H₂₂F₄N₆O₂
Molecular Weight	514.47500
Flash Point	395.2ºC
Exact Mass	514.17400
PSA	78.07000
LogP	4.73470
Storage condition	2-8℃

2,2,2-Trifluoro...

CAS#:6226-25-1

6-fluoro-3-(4-(...

CAS#:1093978-67-6

gamma-secretase...

CAS#:1093978-89-2

Literature: WO2008/156580 A1, ; Page/Page column 43-44 ; WO 2008/156580 A1

Precursor 2
CAS#:6226-25-1 2,2,2-Trifluoro... CAS#:1093978-67-6 6-fluoro-3-(4-(...
DownStream 0

2H-1-Benzopyran-2-carbonitrile,6-fluoro-3,4-dihydro-4-oxo

6-fluoro-3-{4-[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]-1H-1,2,3-triazol-1-yl}-1-(2,2,2-trifluoroethyl)-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

6-fluoro-3,4-dihydro-4-oxo-2H-1-benzopyran-2-carbonitrile

gamma-secretase modulator 2