AZD 3147
Modify Date: 2024-01-05 16:55:24
AZD 3147 structure
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Common Name | AZD 3147 | ||
|---|---|---|---|---|
| CAS Number | 1101810-02-9 | Molecular Weight | 517.664 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 696.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C24H31N5O4S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 375.2±34.3 °C | |
Use of AZD 3147AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1]. |
| Name | AZD3147 |
|---|---|
| Synonym | More Synonyms |
| Description | AZD3147 is a potent, orally active, selective dual inhibitor of mTORC1 and mTORC2 with an IC50 value of 1.5 nM. AZD3147 also has a selective effect on PI3K[1]. |
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| Related Catalog | |
| Target |
mTORC1 mTORC2 |
| In Vitro | AZD3147 (0-50 nM, 1 h) can alleviate fibroblast growth factor (FGF)-mediated cilia extension at concentrations above 1.5 nM in NIH3T3 cells[2]. AZD3147 inhibits cell viability of neuroblastoma cell lines Kelly and IMR-32 with the IC50 values of 0.88 nM and 662.4 nM, respectively[3]. |
| In Vivo | The pharmacokinetic parameters of AZD3147[1]. Parameter Mouse Dog CL (mL/min/kg) 78 16 Vss (L/kg) 2.3 2.2 t1/2(h) 0.9 1.9 F% 61 73 |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 696.7±65.0 °C at 760 mmHg |
| Molecular Formula | C24H31N5O4S2 |
| Molecular Weight | 517.664 |
| Flash Point | 375.2±34.3 °C |
| Exact Mass | 517.181763 |
| LogP | -0.58 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.689 |
| 1-(4-{4-[1-(Cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl}phenyl)-3-(2-hydroxyethyl)thiourea |
| Thiourea, N-[4-[4-[1-(cyclopropylsulfonyl)cyclopropyl]-6-[(3S)-3-methyl-4-morpholinyl]-2-pyrimidinyl]phenyl]-N'-(2-hydroxyethyl)- |