Ch 55
Modify Date: 2024-01-10 20:17:39
Ch 55 structure
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Common Name | Ch 55 | ||
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| CAS Number | 110368-33-7 | Molecular Weight | 364.47700 | |
| Density | 1.085g/cm3 | Boiling Point | 509.5ºC at 760mmHg | |
| Molecular Formula | C24H28O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 276ºC | |
Use of Ch 55Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. |
| Name | 4-[(E)-3-(3,5-ditert-butylphenyl)-3-oxoprop-1-enyl]benzoic acid |
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| Synonym | More Synonyms |
| Description | Ch55 is a potent synthetic retinoid. Ch55 binds to RAR-α and RAR-β receptors with high affinity. Ch55 displays low affinity for cellular retinoic acid binding protein (CRABP). Ch55 is a potent inducer of the differentiation of HL60 cells with an EC50 of 200 nM. Ch55 can be used for cancer research[1][2]. |
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| Related Catalog | |
| Target |
RARα RARβ |
| In Vitro | Ch55 inhibits squamous cell differentiation of rabbit tracheal epithelial cells by inhibiting type I transglutaminase activity (EC50 = 0.02 nM) and increasing cholesterol sulfate levels (EC50 = 0.03 nM). Ch55 also induce differentiation of embryonic carcinoma F9 cells and melanoma S91 cells (EC50s = 0.26 and 0.5 nM, respectively), and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM)[1]. |
| References |
| Density | 1.085g/cm3 |
|---|---|
| Boiling Point | 509.5ºC at 760mmHg |
| Molecular Formula | C24H28O3 |
| Molecular Weight | 364.47700 |
| Flash Point | 276ºC |
| Exact Mass | 364.20400 |
| PSA | 54.37000 |
| LogP | 5.87590 |
| Vapour Pressure | 3.33E-11mmHg at 25°C |
| Index of Refraction | 1.574 |
| HS Code | 2918300090 |
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| HS Code | 2918300090 |
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| Summary | 2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
| 3,5-di-tert-butylchalcone 4'-carboxylic acid |
| CH 55 |
| 3,5-Di-tert-butylchalcone |