174688-78-9

174688-78-9 structure

Name: CH 275
Chemical Name: CH 275
CAS Number: 174688-78-9
Molecular Formula: C₇₄H₉₆N₁₄O₁₅S₂
Molecular Weight: 1485.77
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2020-08-07 16:40:35
Modify Date: 2024-01-10 11:24:53
CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively[1]. CH 275 can be used for the research of Alzheimer’s disease[2].

Name	CH 275

Description	CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively[1]. CH 275 can be used for the research of Alzheimer’s disease[2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Neurological Disease
In Vitro	CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron[1].
In Vivo	CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the App knock-in mice[1]. CH275 directly injects into the Lmol layer of 2-month-old AppNL-G-Fmice for four months. AppNL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects[1].
References	[1]. J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem. 2001 Jun 21;44(13):2238-46. [2]. J E Rivier, et al. Potent somatostatin undecapeptide agonists selective for somatostatin receptor 1 (sst1). J Med Chem. 2001 Jun 21;44(13):2238-46.

Molecular Formula	C₇₄H₉₆N₁₄O₁₅S₂
Molecular Weight	1485.77