(2-pyridyldithio)-PEG1-hydrazine

Modify Date: 2024-01-29 23:43:43

(2-pyridyldithio)-PEG1-hydrazine Structure
(2-pyridyldithio)-PEG1-hydrazine structure
Common Name (2-pyridyldithio)-PEG1-hydrazine
CAS Number 111625-28-6 Molecular Weight 187.283
Density 1.3±0.1 g/cm3 Boiling Point 323.3±38.0 °C at 760 mmHg
Molecular Formula C7H9NOS2 Melting Point N/A
MSDS N/A Flash Point 149.3±26.8 °C

 Use of (2-pyridyldithio)-PEG1-hydrazine


(2-pyridyldithio)-PEG1-hydrazine is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name S-2-pyridyl-S'-2-hydroxyethyl disulfide
Synonym More Synonyms

 (2-pyridyldithio)-PEG1-hydrazine Biological Activity

Description (2-pyridyldithio)-PEG1-hydrazine is a cleavable 1 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 323.3±38.0 °C at 760 mmHg
Molecular Formula C7H9NOS2
Molecular Weight 187.283
Flash Point 149.3±26.8 °C
Exact Mass 187.012558
PSA 83.72000
LogP 2.08
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.646

 Safety Information

Hazard Codes C

 Synonyms

Ethanol, 2-(2-pyridinyldithio)-
.2-(2-(pyridin-2-yl)disulfanyl)ethanol
.2-hydroxyethyl 2-pyridyl disulfide
2-Pyr-SSCH2CH2OH
2-(2-Pyridinyldisulfanyl)ethanol
.2-(pyridine-2-yl-disulfanyl)ethanol
2-(2-(pyridin-2-yl)disulfanyl)ethanol
.2-(2-hydroxyethyldithio)-pyridine
.2-(pyridin-2-yldisulfanyl)ethanol