Olmesartan Medoxomil-d6

Modify Date: 2024-01-09 11:36:37

Olmesartan Medoxomil-d6 structure	Common Name	Olmesartan Medoxomil-d6
	CAS Number	1127298-67-2	Molecular Weight	564.62200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₉H₂₄D₆N₆O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Olmesartan Medoxomil-d6

Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM[1][2].

Name	Olmesartan Medoxomil-d6

Description	Olmesartan medoxomil-d6 (CS 866-d6) is the deuterium labeled Olmesartan medoxomil. Olmesartan medoxomil is a potent and selective angiotensin AT1 receptor inhibitor with IC50 of 66.2 μM[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Senda A, et al. Effects of Angiotensin II Receptor Blockers on Metabolism of Arachidonic Acid via CYP2C8. Biol Pharm Bull. 2015;38(12):1975-9. [3]. Shah S, et al. Simultaneous Quantitative Analysis of Olmesartan Medoxomil and Amlodipine Besylate in Plasma by High-performance Liquid Chromatography Technique. J Young Pharm. 2012 Apr;4(2):88-94. [4]. Gu J, et al. Olmesartan Prevents Microalbuminuria in db/db Diabetic Mice Through Inhibition of Angiotensin II/p38/SIRT1-Induced Podocyte Apoptosis. Kidney Blood Press Res. 2016 Nov 21;41(6):848-864.

Molecular Formula	C₂₉H₂₄D₆N₆O₆
Molecular Weight	564.62200
Exact Mass	564.26000
PSA	162.16000
LogP	4.17000

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Olmesartan Medoxomil-d6
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Purity: 99.0%
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