3-Deoxysappanone B

Modify Date: 2024-06-22 09:47:32

3-Deoxysappanone B structure	Common Name	3-Deoxysappanone B
	CAS Number	113122-54-6	Molecular Weight	286.279
	Density	1.5±0.1 g/cm3	Boiling Point	587.4±50.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₄O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	225.0±23.6 °C

Use of 3-Deoxysappanone B

Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].

Name	3-(3,4-Dihydroxybenzyl)-7-hydroxy-2,3-dihydro-4H-chromen-4-one
Synonym	More Synonyms

Description	Deoxysappanone B (3-Deoxysappanone B) is a homoisoflavone compound isolated from Caesalpinia sappan L (Lignum Sappan). Deoxysappanone B has anti-neuroinflammatory and neuroprotective effects and inhibits the production of neuroinflammatory mediators by blocking the IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Deoxysappanone B can be used in disease studies of neuritis and inflammation-related neurological damage[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
References	[1]. Ke-Wu Zeng, et al. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinase (IKK)-NF-κB and p38/ERK MAPK pathways. Eur J Pharmacol. 2015 Feb 5;748:18-29.

Density	1.5±0.1 g/cm3
Boiling Point	587.4±50.0 °C at 760 mmHg
Molecular Formula	C₁₆H₁₄O₅
Molecular Weight	286.279
Flash Point	225.0±23.6 °C
Exact Mass	286.084137
PSA	86.99000
LogP	2.61
Vapour Pressure	0.0±1.7 mmHg at 25°C
Index of Refraction	1.684