Cefoperazone dihydrate

Modify Date: 2024-01-09 20:17:44

Cefoperazone dihydrate Structure
Cefoperazone dihydrate structure
Common Name Cefoperazone dihydrate
CAS Number 113826-44-1 Molecular Weight 645.667
Density 1.8±0.1 g/cm3 Boiling Point N/A
Molecular Formula C25H27N9O8S2 Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08
Signal Word Danger

 Use of Cefoperazone dihydrate


Cefoperazone dihydrate, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity[1].

 Names

Name (6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,dihydrate
Synonym More Synonyms

 Cefoperazone dihydrate Biological Activity

Description Cefoperazone dihydrate, a semisynthetic cephalosporin, has a broad spectrum of antibacterial activity[1].
Related Catalog
In Vitro Cefoperazone (Aerosol treatment, 60 μg/mL final concentration in lung homogenate) protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia[2].
References

[1]. N Matsubara, et al. In vitro antibacterial activity of cefoperazone (T-1551), a new semisynthetic cephalosporin. Antimicrob Agents Chemother. 1979 Dec;16(6):731-5.

[2]. Pedro H.Di Rocco, et al. Aerosol treatment with cefoperazone or gentamicin protects granulocytopenic mice from acute Pseudomonas aeruginosa pneumonia. European Journal of Pharmaceutical Sciences Volume 1, Issue 6, June 1994, Pages 285-289.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Molecular Formula C25H27N9O8S2
Molecular Weight 645.667
Exact Mass 645.142395
PSA 296.30000
LogP 1.43
Index of Refraction 1.819
Storage condition 2-8°C

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P284-P304 + P340-P342 + P311
Hazard Codes Xn
Risk Phrases 42/43
Safety Phrases 22-36/37-45
RIDADR NONH for all modes of transport

 Synonyms

Cefoperazone
HMS1569A15
(6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
HMS2096A15
acide (6R,7R)-7-{[(2R)-2-{[(4-éthyl-2,3-dioxopipérazin-1-yl)carbonyl]amino}-2-(4-hydroxyphényl)acétyl]amino}-3-{[(1-méthyl-1H-tétrazol-5-yl)sulfanyl]méthyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ène-2
CP 52640-2
(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid dihydrate
CEFOBID
Cefobis
5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-
7-[D-(-)-a-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-a-(4-hydroxyphenyl)acetamido]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-3-cephem-4-carboxylic Acid
(6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
(6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)thio]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Cefoperazone dihydrate
Prestwick_735
(6R,7R)-7-{[(2R)-2-{[(4-Ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carbon
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, (6R,7R)-
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