Cefoperazone sodium

Modify Date: 2024-01-03 11:18:02

Cefoperazone sodium Structure
Cefoperazone sodium structure
 Common Name Cefoperazone sodium
CAS Number 62893-20-3 Molecular Weight 667.649
Density N/A Boiling Point N/A
Molecular Formula C25H26N9NaO8S2 Melting Point 200-202°C
MSDS Chinese USA Flash Point N/A
Symbol GHS08
GHS08		 Signal Word Danger

 Use of Cefoperazone sodium


Cefoperazone sodium salt is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.Target: AntibacterialCefoperazone is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.

 Names

Name sodium,(6R,7R)-7-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Synonym More Synonyms

 Cefoperazone sodium Biological Activity

Description Cefoperazone sodium salt is a cephalosporin antibiotic for inhibition of rMrp2-mediated [3H]E217βG uptake with IC50 of 199 μM.Target: AntibacterialCefoperazone is a sterile, semisynthetic, broad-spectrum, parenteral cephalosporin antibiotic for intravenous or intramuscular administration. After intravenous administration of 2 g of Cefoperazone, levels in serum rang from 202μg/mL to 375 μg/mL depending on the period of drug administration. After intramuscular injection of 2 g of Cefoperazone, the mean peak serum level is 111 μg/mL at 1.5 hours. At 12 hours after dosing, mean serum levels are still 2 to 4 μg/mL. Cefoperazone is 90% bound to serum proteins.
Related Catalog
References

[1]. Kato, Y., et al., Involvement of multidrug resistance-associated protein 2 (Abcc2) in molecular weight-dependent biliary excretion of beta-lactam antibiotics. Drug Metab Dispos, 2008. 36(6): p. 1088-96.

[2]. Craig, W.A. and A.U. Gerber, Pharmacokinetics of cefoperazone: a review. Drugs, 1981. 22 Suppl 1: p. 35-45.

 Chemical & Physical Properties

Melting Point 200-202°C
Molecular Formula C25H26N9NaO8S2
Molecular Weight 667.649
Exact Mass 667.124329
PSA 273.69000
Water Solubility H2O: 50 mg/mL, clear, faintly yellow

 Safety Information

Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P342 + P311
Hazard Codes Xn:Harmful
Risk Phrases R42/43
Safety Phrases S22-S36/37
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS XI0374000
HS Code 2941905600

 Synthetic Route

Cefoperazone structure

Cefoperazone

CAS#:62893-19-0

~97%

Cefoperazone sodium Structure

Cefoperazone sodium

CAS#:62893-20-3

Literature: DSM SINOCHEM PHARMACEUTICALS NETHERLANDS B.V.; MAO, Chang-Long; XU, Jian-Jun; SONG, Bo Patent: WO2014/12849 A1, 2014 ; Location in patent: Page/Page column 6; 7 ;

 Precursor & DownStream

Precursor  1

DownStream  0

 Customs

HS Code 2941905600

 Articles30

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The objective of this study was to compare the effectiveness of piperacillin-tazobactam (PIP/TAZO) plus amikacin (AMK) (PIP/TAZO+AMK) versus cefoperazone-sulbactam (CS) plus AMK (CS+AMK) for the treat...

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 Synonyms

Cefoperazone sodium
MFCD07793331
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-[[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-, sodium salt, (6R,7R)- (1:1)
Sodium (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
Sodium (6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
cefoperazone-Na
Natrium-(6R,7R)-7-{[(2R)-2-{[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino}-2-(4-hydroxyphenyl)acetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylat
Sodium cefoperazone
cefoperazone monosodium
EINECS 263-751-5
Tomabef
cephoperazone sodium
Cefoperazone sodium [USAN:JAN]
Cefoperazone sodium salt
CEFOBID IN PLASTIC CONTAINER
T 1551
Cefoperazone sodium (JP15/USP)
Cefoperazonesodium
Cefoperazone (sodium salt)
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