19(S)-HETE
Modify Date: 2024-01-03 00:27:23
19(S)-HETE structure
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Common Name | 19(S)-HETE | ||
|---|---|---|---|---|
| CAS Number | 115461-40-0 | Molecular Weight | 320.466 | |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 477.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H32O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 256.6±25.2 °C | |
Use of 19(S)-HETE19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1]. |
| Name | 19(s)-hete |
|---|---|
| Synonym | More Synonyms |
| Description | 19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1]. |
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| Related Catalog | |
| In Vitro | 19(S)-HETE (1 μM; 15 min) 剂量依赖性诱导 cAMP 在 MEG-01 细胞中增加，EC50 值为 520 nM[1]。 19(S)-HETE (1 μM-1 M) 剂量依赖性地激活环前列腺素受体，EC50 值为 567 nM[1]。 19(S)-HETE (10 μM-1 M) 取代 3H-iloprost，在表达的环前列腺素受体的 COS-1 细胞，Ki 值为 660 nM[1]。 19(S)-HETE (3 μM) 可松弛动脉血管，抑制血小板活化[1]。 |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 477.3±45.0 °C at 760 mmHg |
| Molecular Formula | C20H32O3 |
| Molecular Weight | 320.466 |
| Flash Point | 256.6±25.2 °C |
| Exact Mass | 320.235138 |
| PSA | 57.53000 |
| LogP | 4.79 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.514 |
| 5,8,11,14-Eicosatetraenoic acid, 19-hydroxy-, (5Z,8Z,11Z,14Z,19S)- |
| 19(S)-HETE |
| (5Z,8Z,11Z,14Z,19S)-19-Hydroxy-5,8,11,14-icosatetraenoic acid |