115461-40-0

115461-40-0 structure

Name: 19(S)-HETE
Chemical Name: 19(s)-hete
CAS Number: 115461-40-0
Molecular Formula: C₂₀H₃₂O₃
Molecular Weight: 320.466
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2016-06-10 03:42:25
Modify Date: 2024-01-03 00:27:23
19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1].

Name	19(s)-hete
Synonyms	5,8,11,14-Eicosatetraenoic acid, 19-hydroxy-, (5Z,8Z,11Z,14Z,19S)- 19(S)-HETE (5Z,8Z,11Z,14Z,19S)-19-Hydroxy-5,8,11,14-icosatetraenoic acid

Description	19(S)-HETE is an arachidonic acid metabolite produced by cytochrome P450 enzymes. 19(S)-HETE is a full orthosteric agonist of the prostacyclin (IP) receptor with an EC50 value of 567 nM. 19(S)-HETE inhibits platelet activation and relaxation of vessels[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor
In Vitro	19(S)-HETE (1 μM; 15 min) 剂量依赖性诱导 cAMP 在 MEG-01 细胞中增加，EC50 值为 520 nM[1]。 19(S)-HETE (1 μM-1 M) 剂量依赖性地激活环前列腺素受体，EC50 值为 567 nM[1]。 19(S)-HETE (10 μM-1 M) 取代 3H-iloprost，在表达的环前列腺素受体的 COS-1 细胞，Ki 值为 660 nM[1]。 19(S)-HETE (3 μM) 可松弛动脉血管，抑制血小板活化[1]。
References	[1]. Tunaru S, et al. Arachidonic Acid Metabolite 19(S)-HETE Induces Vasorelaxation and Platelet Inhibition by Activating Prostacyclin (IP) Receptor. PLoS One. 2016 Sep 23;11(9):e0163633.