sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate

Modify Date: 2024-02-17 21:23:08

sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate structure	Common Name	sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate
	CAS Number	115850-11-8	Molecular Weight	566.56500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₄H₂₃N₈NaO₉S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate

Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].

Name	sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate
Synonym	More Synonyms

Description	Cefazolin sodium pentahydrate is a first-generation cephalosporin antibiotic and can be used in varieties of bacterial infections research[1]. Cefazolin sodium pentahydrate has anti-inflammatory effect and can attenuate post-operative cognitive dysfunction (POCD)[2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cefazolin sodium pentahydrate (0-300 μg/ml; 6 or 24 h) has a direct anti-inflammatory effect on C8-B4 cells stimulated by lipopolysaccharide[2]. Cefazolin sodium pentahydrate (0-400 μM; 72 h) treatment inhibits IL-2, IL-4 and IL-15-induced cell proliferation[3]. Cefazolin sodium pentahydrate (0-400 μM; 30 min) treatment inhibits IL-2, IL-4, IL-15 and IL-21-stimulated JAK3 phosphorylation[3]. Cell Viability Assay[2] Cell Line: C8-B4 cells Concentration: 0, 50, 100, 150, 200, 250, or 300 μg/ml Incubation Time: 6 or 24 hours Result: Inhibited the increase of IL-1β at all doses, but inhibited the increase of IL-6 only at 200 μg/ml. Cell Proliferation Assay[3] Cell Line: PBMC, and TF-1 cells Concentration: 0, 100, 200, and 400 μM Incubation Time: 72 hours Result: Reduced IL-2, IL-4 and IL-15-induced cell proliferation, suggested that Cefazolin interferes not only with IL-15Rα, but also with IL-2/IL-15Rβ and/or γc. Western Blot Analysis[3] Cell Line: PBMC, NK-92, and TF-1 cells Concentration: 0, 100, 200, and 400 μM Incubation Time: 30 min Result: Diminished the phosphorylation of JAK3 in response to the cytokine treatment, concluded suppressing signal transduction by γc receptors.
In Vivo	Cefazolin sodium pentahydrate (Subcutaneous injection; 300-500 mg/kg; once daily; 5 d) treatment improves learning and memory in mice after surgery[2]. Animal Model: 6- to 8-week-old male CD-1 mice underwent clinical exploratory laparotomy[2] Dosage: 300-500 mg/kg Administration: Subcutaneous injection; 300-500 mg/kg; once daily; 5 days Result: Attenuated learning and memory dysfunction induced by the surgery.
References	[1]. R Quintiliani, et al. Cefazolin. Ann Intern Med. 1978 Nov;89(5 Pt 1):650-6. [2]. Peng Liang, et al. Perioperative use of cefazolin ameliorates postoperative cognitive dysfunction but induces gut inflammation in mice. J Neuroinflammation. 2018 Aug 22;15(1):235. [3]. Barbara Żyżyńska-Granica, et al. The anti-inflammatory potential of cefazolin as common gamma chain cytokine inhibitor. Sci Rep. 2020 Feb 19;10(1):2886.

Molecular Formula	C₁₄H₂₃N₈NaO₉S₃
Molecular Weight	566.56500
Exact Mass	566.06500
PSA	287.40000

UNII-XLJ4VSY381

Cefazolin sodium hydrate (JP16)

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,3-[[(5-methyl-1,3,4-thiadiazol-2-yl)thio]methyl]-8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-,sodium salt,hydrate (1:1:5),(6R,7R)

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sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate

Use of sodium,(6R,7R)-3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate,pentahydrate

Names

Biological Activity

Chemical & Physical Properties

Synonyms