Bactenecin

Modify Date: 2024-01-02 15:02:25

Bactenecin structure	Common Name	Bactenecin
	CAS Number	116229-36-8	Molecular Weight	1483.89000
	Density	1.43g/cm3	Boiling Point	N/A
	Molecular Formula	C₆₃H₁₁₈N₂₄O₁₃S₂	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Bactenecin

Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.

Name	bactenecin
Synonym	More Synonyms

Description	Bactenecin is a cyclic antimicrobial peptide isolated from bovine neutrophils with potent activity against Bacterial and Fungal species.
Related Catalog	Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> Anti-infection >> Fungal Peptides Research Areas >> Infection
Target	Bacterial, Fungal[1]
In Vitro	Bactenecin inhibits the growth of Escherichia coli and Staphylococcus aureus at the same concentration. Bactenecin inhibits the growth of other medically important bacteria and yeast, and it kills the fungus Trichophyton rubrum. Acetylation and amidation of the amino- and carboxy-termini of bactenecin do not change its potency, while replacement of its two cysteine residues with serine decreases the potency[1]. Bactenecin, a dodecapeptide, is strongly cytotoxic to rat embryonic neurons, fetal rat astrocytes and human glioblastoma cells. This neurotoxicity is unique to bactenecin, as a panel of antibacterial peptides from vertebrates and invertebrates, like defensins corticostatin, indolicidin, cecropin P1, tachyplesin I, the magainins, or apidaecins did not impair neuronal viability[2].
Cell Assay	Rat neuronal cells (5000 cells/well) are incubated for 24 hr with bactenecin (0.3, 0.6, 1.25, 2.5, 5, 10, 20, 40 μg/mL) or the control peptide. Cytotoxicity is assayed in 96-well tissue culture plates using a commercially available kit. The method is based on cellular reduction of tetrazolium salt into intensely coloured formazan derivates.[2].
References	[1]. Gallis B, et al. Antimicrobial activity of synthetic bactenecin. Biotechnol Ther. 1989-1990;1(4):335-46. [2]. Radermacher SW, et al. Bactenecin, a leukocytic antimicrobial peptide, is cytotoxic to neuronal and glial cells. J Neurosci Res. 1993 Dec 15;36(6):657-62.

Density	1.43g/cm3
Molecular Formula	C₆₃H₁₁₈N₂₄O₁₃S₂
Molecular Weight	1483.89000
Exact Mass	1482.88000
PSA	681.62000
LogP	5.55260
Index of Refraction	1.649
Storage condition	2-8℃

Boc-L-Isoleucine structure

Boc-L-Isoleucine

CAS#:13139-16-7

Boc-Leu-OH.H2O structure

Boc-Leu-OH.H2O

CAS#:13139-15-6

Boc-Arg(Tos)-OH structure

Boc-Arg(Tos)-OH

CAS#:13836-37-8

Boc-Cys(pMeOBzl)-OH structure

Boc-Cys(pMeOBzl)-OH

CAS#:18942-46-6

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Detail

Literature: Bulletin of the Chemical Society of Japan, , vol. 65, # 2 p. 615 - 617

Precursor 4
CAS#:13139-16-7 Boc-L-Isoleucine CAS#:13139-15-6 Boc-Leu-OH.H2O CAS#:13836-37-8 Boc-Arg(Tos)-OH CAS#:18942-46-6 Boc-Cys(pMeOBzl)-OH
DownStream 0

R-lactic acid tert-butyl ester

bovine dodecapeptide

D-lactic acid tert-butyl ester

RLCRIVVIRVCR 3-11 disulfide

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Bactenecin
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Purity: 95.0%
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Taiwan Oyi peptide Co. Ltd
China
Product Name: Bactenecin
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
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Price: $110/1mg

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