UC-773587
Modify Date: 2024-08-09 18:21:45
UC-773587 structure
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Common Name | UC-773587 | ||
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| CAS Number | 116679-69-7 | Molecular Weight | 432.431 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C28H16O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UC-773587A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
| Name | UC-773587 |
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| Description | A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction; dose-dependently disrupts the SOS1-Ras interaction by competitively inhibiting the binding of SOS1cat to GDP-bound H-Ras in a microscale thermophoresis assay; dose-dependently inhibits Ras activation and downstream ERK activation mediated through EGFR-SOS1-Ras-Raf1-MEK-ERK signaling, specifically inhibits wild-type mouse embryonic fibroblast growth but not the growth of oncogenic H-Ras(G12V)-expressing mouse embryonic fibroblasts; inhibits Ras signaling and growth of pancreatic and prostate cancer cells. |
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| References | References 1. Evelyn CR, et al. J Biol Chem. 2015 May 15;290(20):12879-98. View Related Products by Target Ras |
| Molecular Formula | C28H16O5 |
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| Molecular Weight | 432.431 |