UC-764865
Modify Date: 2024-04-03 10:48:58
UC-764865 structure
|
Common Name | UC-764865 | ||
|---|---|---|---|---|
| CAS Number | 2566480-63-3 | Molecular Weight | 324.398 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H16N2O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of UC-764865UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
| Name | UC-764865 |
|---|
| Description | UC-764865 (UC764865) is a small-molecule inhibitor that targeted ubiquitin-conjugating enzyme UBE2N active site.UC-764865 blocks ubiquitination of innate immune- and inflammatory-related substrates in human AML cell lines.Inhibition of UBE2N function disrupted oncogenic immune signaling by promoting cell death of leukemic HSPCs while sparing normal HSPCs in vitro. |
|---|---|
| References | 1. Laura Barreyro, et al. Sci Transl Med. 2022 Mar 9;14(635):eabb7695. |
| Molecular Formula | C18H16N2O2S |
|---|---|
| Molecular Weight | 324.398 |