PHM-27 (human)

Modify Date: 2024-01-06 11:47:38

PHM-27 (human) structure	Common Name	PHM-27 (human)
	CAS Number	118025-43-7	Molecular Weight	2985.41000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₅H₂₁₄N₃₄O₄₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PHM-27 (human)

PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].

Name	PHM 27 (human)
Synonym	More Synonyms

Description	PHM-27 (human) is a human prepro-vasoactive intestinal polypeptide (27 amino acid). PHM-27 (human) is a potent the human calcitonin receptor agonist with an EC50 of 11 nM. PHM-27 (human) efficiently enhances glucose-induced insulin secretion from beta cells by an autocrine mechanism[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CGRP Receptor Research Areas >> Cardiovascular Disease Signaling Pathways >> Neuronal Signaling >> CGRP Receptor Research Areas >> Metabolic Disease
Target	EC50: 11 nM (human calcitonin receptor)[2]
References	[1]. N Itoh, et al. Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27. Nature. 1983 Aug 11-17;304(5926):547-9. [2]. Jian-Nong Ma, et al. Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor. Biochem Pharmacol. 2004 Apr 1;67(7):1279-84. [3]. I Kato, et al. Transgenic mice overexpressing human vasoactive intestinal peptide (VIP) gene in pancreatic beta cells. Evidence for improved glucose tolerance and enhanced insulin secretion by VIP and PHM-27 in vivo. J Biol Chem. 1994 Aug 19;269(33):21223-8.

Molecular Formula	C₁₃₅H₂₁₄N₃₄O₄₀S
Molecular Weight	2985.41000
Exact Mass	2983.55000
PSA	1234.12000
LogP	2.92740

phm,human

h-his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2

peptide histidine methionine,human

his-ala-asp-gly-val-phe-thr-ser-asp-phe-ser-lys-leu-leu-gly-gln-leu-ser-ala-lys-lys-tyr-leu-glu-ser-leu-met-nh2

m.w. 2985.41 c135h214n34o40s

PHM-27 (human)

Use of PHM-27 (human)

Names

PHM-27 (human) Biological Activity

Chemical & Physical Properties

Synonyms