Mephenytoin-d3

Modify Date: 2024-01-20 13:24:14

Mephenytoin-d3 Structure
Mephenytoin-d3 structure
Common Name Mephenytoin-d3
CAS Number 1185101-86-3 Molecular Weight 221.27000
Density N/A Boiling Point N/A
Molecular Formula C12H11D3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mephenytoin-d3


(Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

 Names

Name rac Mephenytoin-d3
Synonym More Synonyms

 Mephenytoin-d3 Biological Activity

Description (Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64(4):387-398.

[3]. Relling MV, et al. Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections. Pharmacogenetics. 1991;1(1):42-49.

 Chemical & Physical Properties

Molecular Formula C12H11D3N2O2
Molecular Weight 221.27000
Exact Mass 221.12400
PSA 52.90000
LogP 1.05140

 Synonyms

5-ethyl-5-phenyl-3-(trideuteriomethyl)imidazolidine-2,4-dione