1185101-86-3

1185101-86-3 structure

Name: Mephenytoin-d3
Chemical Name: rac Mephenytoin-d3
CAS Number: 1185101-86-3
Molecular Formula: C₁₂H₁₁D₃N₂O₂
Molecular Weight: 221.27000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Cytochrome P450
Create Date: 2017-04-20 10:57:50
Modify Date: 2024-01-20 13:24:14
(Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].

Name	rac Mephenytoin-d3
Synonyms	5-ethyl-5-phenyl-3-(trideuteriomethyl)imidazolidine-2,4-dione

Description	(Rac)-Mephenytoin-d3 is a labelled racemic Mephenytoin. Mephenytoin, an anticonvulsant, is the CYP2C19 and CYP2B6 substrate[1].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Klaassen T, et al. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity. Eur J Clin Pharmacol. 2008;64(4):387-398. [3]. Relling MV, et al. Mephenytoin phenotyping: lack of haematologic effect and timing of urine collections. Pharmacogenetics. 1991;1(1):42-49.