BI-409306
Modify Date: 2024-01-07 21:05:41
BI-409306 structure
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Common Name | BI-409306 | ||
|---|---|---|---|---|
| CAS Number | 1189767-28-9 | Molecular Weight | 311.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BI-409306BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders. |
| Name | BI-409306 |
|---|
| Description | BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM); BI-409306 can be used in the research of memory enhancement in CNS disorders. |
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| Related Catalog | |
| Target |
PDE9A:52 nM (IC50) PDE1C:1 μM (IC50) PDE1A:1.4 μM (IC50) |
| In Vitro | BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM, and shows weak activity against other PDEs, such as PDE1A (IC50, 1.4 µM), PDE1C (IC50, 1.0 µM), PDE2A, PDE3A, PDE4B, PDE5A, PDE6AB, PDE7A, and PDE10A (IC50 all > 10 μM), and has no obvious effect on 95 non-PDE targets at 10 µM. BI-409306 enhances long-term potentiation (LTP) in rat hippocampal slices[1]. |
| References |
| Molecular Formula | C16H17N5O2 |
|---|---|
| Molecular Weight | 311.34 |
| Storage condition | 2-8℃ |