Isradipine-d3

Modify Date: 2024-01-14 12:36:41

Isradipine-d3 Structure
Isradipine-d3 structure
Common Name Isradipine-d3
CAS Number 1189959-59-8 Molecular Weight 374.40600
Density N/A Boiling Point N/A
Molecular Formula C19H18D3N3O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Isradipine-d3


Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].

 Names

Name 3-O-propan-2-yl 5-O-(trideuteriomethyl) 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
Synonym More Synonyms

 Isradipine-d3 Biological Activity

Description Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease[1][2][3].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Ilijic E, et al. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Neurobiol Dis. 2011;43(2):364-371.

[3]. Campbell CA, et al. Effects of isradipine, an L-type calcium channel blocker on permanent and transient focal cerebral ischemia in spontaneously hypertensive rats. Exp Neurol. 1997;148(1):45-50.

[4]. Hof RP, et al. Selective effects of PN 200-110 (isradipine) on the peripheral circulation and the heart. Am J Cardiol. 1987;59(3):30B-36B.

 Chemical & Physical Properties

Molecular Formula C19H18D3N3O5
Molecular Weight 374.40600
Exact Mass 374.16700
PSA 103.55000
LogP 2.91100

 Synonyms

Esradin-d3
Prescal-d3
Clivoten-d3
DynaCirc-d3
Isrodipine-3
Isradipine-d3
Lomir-d3
[2H3]-Isradipine