Thiamphenicol-d3

Modify Date: 2024-01-11 20:59:09

Thiamphenicol-d3 Structure
Thiamphenicol-d3 structure
Common Name Thiamphenicol-d3
CAS Number 2211914-19-9 Molecular Weight 359.24
Density N/A Boiling Point N/A
Molecular Formula C12H12D3Cl2NO5S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thiamphenicol-d3


Thiamphenicol-d3 is deuterium labeled Thiamphenicol. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].

 Names

Name Thiamphenicol-d3

 Thiamphenicol-d3 Biological Activity

Description Thiamphenicol-d3 is deuterium labeled Thiamphenicol. Thiamphenicol (Thiophenicol), a methyl-sulfonyl derivative of Chloramphenicol, is a broad-spectrum antimicrobial antibiotic. Thiamphenicol acts by binding to the 50S ribosomal subunit, leading to inhibition of protein synthesis and bacteriostatic effect (against Gram-negative, Gram-positive aerobic and anaerobic bacteria)[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. A Marchese, et al. In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. J Chemother. 2002 Dec;14(6):554-61.

[3]. Marta Tikhomirov, et al. Pharmacokinetics of florfenicol and thiamphenicol in ducks. J Vet Pharmacol Ther. 2019 Jan;42(1):116-120.

 Chemical & Physical Properties

Molecular Formula C12H12D3Cl2NO5S
Molecular Weight 359.24