4-Bromobutylphosphonic acid

Modify Date: 2024-01-12 17:51:12

4-Bromobutylphosphonic acid Structure
4-Bromobutylphosphonic acid structure
Common Name 4-Bromobutylphosphonic acid
CAS Number 1190-14-3 Molecular Weight 216.99800
Density N/A Boiling Point N/A
Molecular Formula C4H10BrO3P Melting Point 129 °C
MSDS N/A Flash Point N/A

 Use of 4-Bromobutylphosphonic acid


4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name (4-bromobutyl)phosphonic acid
Synonym More Synonyms

 4-Bromobutylphosphonic acid Biological Activity

Description 4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Melting Point 129 °C
Molecular Formula C4H10BrO3P
Molecular Weight 216.99800
Exact Mass 215.95500
PSA 67.34000
LogP 1.33920

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

.(4-bromo-butyl)-phosphonic acid
.4-Brom-butanphosphonsaeure
4-bromobutylphosphonic acid
.4-Brom-butan-phosphonsaeure-(1)
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