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1190-14-3

1190-14-3 structure
1190-14-3 structure
  • Name: 4-Bromobutylphosphonic acid
  • Chemical Name: (4-bromobutyl)phosphonic acid
  • CAS Number: 1190-14-3
  • Molecular Formula: C4H10BrO3P
  • Molecular Weight: 216.99800
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2017-07-27 03:29:04
  • Modify Date: 2024-01-12 17:51:12
  • 4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name (4-bromobutyl)phosphonic acid
Synonyms .(4-bromo-butyl)-phosphonic acid
.4-Brom-butanphosphonsaeure
4-bromobutylphosphonic acid
.4-Brom-butan-phosphonsaeure-(1)
Description 4-Bromobutylphosphonic acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl-Chain

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Melting Point 129 °C
Molecular Formula C4H10BrO3P
Molecular Weight 216.99800
Exact Mass 215.95500
PSA 67.34000
LogP 1.33920
Precursor  0

DownStream  1