Glychionide A

Modify Date: 2024-01-02 16:53:11

Glychionide A Structure
Glychionide A structure
Common Name Glychionide A
CAS Number 119152-50-0 Molecular Weight 446.361
Density 1.7±0.1 g/cm3 Boiling Point 839.4±65.0 °C at 760 mmHg
Molecular Formula C21H18O11 Melting Point 216-217 °C
MSDS N/A Flash Point 298.2±27.8 °C

 Use of Glychionide A


Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].

 Names

Name 58792ZUT0H
Synonym More Synonyms

 Glychionide A Biological Activity

Description Glychionide A is a flavonoside that can be found in the roots of Glychirriza glabra. Glychionide A promotes apoptosis and autophagy of PANC-1 pancreatic cancer cells. Glychionide A can be used for the research of cancer[1][2].
Related Catalog
In Vitro Glychionide A (3.12-100 μM) significantly inhibits the proliferation of the PANC-1 pancreatic cancer cells, with an IC50 of 14 μM[1]. Glychionide A (7-28 μM) induces both autophagy and apoptosis in pancreatic cancer cells[1]. Glychionide A (7-28 μM) causes G2/M arrest of PANC-1 pancreatic cancer cells[1]. Glychionide A (7-28 μM) causes generation of ROS in PANC-1 cells[1].
References

[1]. Li JR, et, al. Two new compounds from Glycyrrhiza glabra. J Asian Nat Prod Res. 2005 Aug;7(4):677-80.

[2]. Yu L, et, al. Antitumor Effects of Glychionide-A Flavonoid in Human Pancreatic Carcinoma Cells Are Mediated by Activation of Apoptotic and Autophagic Pathways, Cell Cycle Arrest, and Disruption of Mitochondrial Membrane Potential. Med Sci Monit. 2019 Feb 3;25:962-969.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 839.4±65.0 °C at 760 mmHg
Melting Point 216-217 °C
Molecular Formula C21H18O11
Molecular Weight 446.361
Flash Point 298.2±27.8 °C
Exact Mass 446.084900
LogP -1.03
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.740

 Safety Information

Hazard Codes Xi

 Synonyms

GLYCHIONIDE A
5,8-Dihydroxy-4-oxo-2-phenyl-4H-chromen-7-yl β-D-glucopyranosiduronic acid
58792ZUT0H
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5,8-dihydroxy-2-phenyl-
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