N-tert-Butyl-α-phenylnitrone-d14

Modify Date: 2024-01-15 05:49:29

N-tert-Butyl-α-phenylnitrone-d14 structure	Common Name	N-tert-Butyl-α-phenylnitrone-d14
	CAS Number	119391-92-3	Molecular Weight	191.329
	Density	1.0±0.1 g/cm3	Boiling Point	283.3±23.0 °C at 760 mmHg
	Molecular Formula	C₁₁HD₁₄NO	Melting Point	N/A
	MSDS	N/A	Flash Point	118.5±15.4 °C

Use of N-tert-Butyl-α-phenylnitrone-d14

N-tert-Butyl-α-phenylnitrone-d14 is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].

Name	n-tert-butyl-d9-phenyl-d5-nitrone
Synonym	More Synonyms

Description	N-tert-Butyl-α-phenylnitrone-d14 is the deuterium labeled N-tert-Butyl-α-phenylnitrone[1]. N-tert-Butyl-α-phenylnitrone is a nitrone-based free radical scavenger that forms nitroxide spin adducts. N-tert-Butyl-α-phenylnitrone inhibits COX2 catalytic activity. N-tert-Butyl-α-phenylnitrone has potent ROS scavenging, anti-inflammatory, neuroprotective, anti-aging and anti-diabetic activities, and can penetrate the blood-brain barrier[2][3][4][5].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> COX
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10. [3]. Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May103(1):149-57. [4]. Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 191448(1):77-84. [5]. R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec222(3):236-45.

Density	1.0±0.1 g/cm3
Boiling Point	283.3±23.0 °C at 760 mmHg
Molecular Formula	C₁₁HD₁₄NO
Molecular Weight	191.329
Flash Point	118.5±15.4 °C
Exact Mass	191.203232
PSA	28.75000
LogP	1.25
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.552

Benzaldehyde

CAS#:14132-51-5

1,1,1,3,3,3-hex...

CAS#:52168-52-2

~61%

N-tert-Butyl-α-...

CAS#:119391-92-3

Literature: Haire, D. Lawrence; Janzen, Edward G. Magnetic Resonance in Chemistry, 1994 , vol. 32, # 3 p. 151 - 157

Precursor 2
CAS#:14132-51-5 Benzaldehyde CAS#:52168-52-2 1,1,1,3,3,3-hex...
DownStream 0

Phenyl-n-propyl-dimethylsilan

N-[2-(H)Methyl(H)-2-propanyl]-N-[(Z)-(H)phenylmethylene]amine oxide

phenyl-N-tert-butylnitrone-d14

Silane,dimethylphenylpropyl

Azane, [1,1-di(methyl-d)ethyl-2,2,2-d](phenyl-d-methylene)-, oxide, (Z)-

Dimethyl-phenyl-n-propylsilan

Phenyl-dimethyl-propyl-silan

N-[2-(H)Methyl(H)propan-2-yl]-N-[(Z)-(H)phenylmethylene]amine oxide

N-tert-Butyl-α-phenylnitrone-d14

Use of N-tert-Butyl-α-phenylnitrone-d14

Names

N-tert-Butyl-α-phenylnitrone-d14 Biological Activity

Chemical & Physical Properties

Synthetic Route

Precursor & DownStream

Synonyms