1,3-Diphenylpropane-1,3-dione

Modify Date: 2024-01-02 10:05:39

1,3-Diphenylpropane-1,3-dione Structure
1,3-Diphenylpropane-1,3-dione structure
 Common Name 1,3-Diphenylpropane-1,3-dione
CAS Number 120-46-7 Molecular Weight 224.255
Density 1.1±0.1 g/cm3 Boiling Point 357.4±0.0 °C at 760 mmHg
Molecular Formula C15H12O2 Melting Point 77-79 °C(lit.)
MSDS Chinese USA Flash Point 146.9±20.2 °C

 Use of 1,3-Diphenylpropane-1,3-dione


Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].

 Names

Name dibenzoylmethane
Synonym More Synonyms

 1,3-Diphenylpropane-1,3-dione Biological Activity

Description Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
Related Catalog
In Vitro Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h[1]. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.Dibenzoylmethane does not show significant cytotoxicity[1].
In Vivo Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice[1]. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice[1].
References

[1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 357.4±0.0 °C at 760 mmHg
Melting Point 77-79 °C(lit.)
Molecular Formula C15H12O2
Molecular Weight 224.255
Flash Point 146.9±20.2 °C
Exact Mass 224.083725
PSA 34.14000
LogP 3.04
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.584
Storage condition Store at RT.
Stability Stable. Incompatible with strong oxidizing agents.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ1930000
CHEMICAL NAME :
1,3-Propanedione, 1,3-diphenyl-
CAS REGISTRY NUMBER :
120-46-7
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C15-H12-O2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4833 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TZ1930000
HS Code 2914399090

 Synthetic Route

 Customs

HS Code 2914399090
Summary 2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

 Articles29

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 Synonyms

1,3-Diphenyl-1,3-propanedione
1,3-diphenylpropane-1,3-dione
Dibenzoylmethane
MFCD00003085
phenacyl phenyl ketone
EINECS 204-398-9
1,3-Propanedione, 1,3-diphenyl-
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