120-46-7

120-46-7 structure

Name: 1,3-Diphenylpropane-1,3-dione
Chemical Name: dibenzoylmethane
CAS Number: 120-46-7
Molecular Formula: C₁₅H₁₂O₂
Molecular Weight: 224.255
Catalog: Chemical reagent Organic reagent Aromatic ketone
Create Date: 2018-07-22 16:56:38
Modify Date: 2024-01-02 10:05:39
Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].

Name	dibenzoylmethane
Synonyms	1,3-Diphenyl-1,3-propanedione 1,3-diphenylpropane-1,3-dione Dibenzoylmethane MFCD00003085 phenacyl phenyl ketone EINECS 204-398-9 1,3-Propanedione, 1,3-diphenyl-

Description	Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> Keap1-Nrf2 Research Areas >> Metabolic Disease
In Vitro	Dibenzoylmethane (10, 20, 30, 40, 50 μM; 6 hours) treatment concentration-dependently increases the mRNA level of HO-1 but has no effect on the mRNA level of Nrf2 in HepG2 cells. Dibenzoylmethane induces HO-1 and Nrf2 protein expression, and the induction diminishes after 12 h[1]. Dibenzoylmethane (10, 20, 30, 40, 50 μM; 2 hours) concentration-dependently increases the phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells.Dibenzoylmethane does not show significant cytotoxicity[1].
In Vivo	Dibenzoylmethane (200, 500 mg/kg/day; ip; for three consecutive days) pretreatment significantly reduces both the area and the severity of necrosis, as well as the leukocyte infiltration, at a dose of 200 mg/kg in wild-type and Nrf2 knockout mice[1]. Dibenzoylmethane protectes against CCl4-induced (1:49,v/v, 10 ml/kg) liver damage in wild-type mice[1].
References	[1]. Mingnan Cao, et al. Dibenzoylmethane Protects Against CCl4-Induced Acute Liver Injury by Activating Nrf2 via JNK, AMPK, and Calcium Signaling. AAPS J. 2017 Nov;19(6):1703-1714.

Density	1.1±0.1 g/cm3
Boiling Point	357.4±0.0 °C at 760 mmHg
Melting Point	77-79 °C(lit.)
Molecular Formula	C₁₅H₁₂O₂
Molecular Weight	224.255
Flash Point	146.9±20.2 °C
Exact Mass	224.083725
PSA	34.14000
LogP	3.04
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.584
Storage condition	Store at RT.
Stability	Stable. Incompatible with strong oxidizing agents.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,28,1953 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4833 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	TZ1930000
HS Code	2914399090

HS Code	2914399090
Summary	2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%