ICI 204,448 hydrochloride
ICI 204,448 hydrochloride structure
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Common Name | ICI 204,448 hydrochloride | ||
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| CAS Number | 121264-04-8 | Molecular Weight | 501.83 | |
| Density | N/A | Boiling Point | 638.9ºC at 760 mmHg | |
| Molecular Formula | C23H27Cl3N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 340.2ºC | |
Use of ICI 204,448 hydrochlorideICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1]. |
| Name | 2-[3-[1-[[2-(3,4-dichlorophenyl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenoxy]acetic acid,hydrochloride |
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| Synonym | More Synonyms |
| Description | ICI-204448 is a κ-opioid agonist with limited access to the CNS, ICI-204448 can displace the binding of the kappa-opioid ligand 3H-bremazocine from guinea pig cerebellum membranes[1]. |
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| Related Catalog | |
| References |
| Boiling Point | 638.9ºC at 760 mmHg |
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| Molecular Formula | C23H27Cl3N2O4 |
| Molecular Weight | 501.83 |
| Flash Point | 340.2ºC |
| Exact Mass | 500.10400 |
| PSA | 70.08000 |
| LogP | 5.03470 |
| Vapour Pressure | 3.39E-17mmHg at 25°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
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Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.
Proc. Natl. Acad. Sci. U. S. A. 105(49) , 19038-43, (2008) Previous work from our group showed that intrathecal (i.t.) administration of substances such as glutamate, NMDA, or PGE(2) induced sensitization of the primary nociceptive neuron (PNN hypernociceptio... |
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Effects of peripherally restricted κ opioid receptor agonists on pain-related stimulation and depression of behavior in rats.
J. Pharmacol. Exp. Ther. 340(3) , 501-9, (2012) κ opioid receptor agonists that do not readily cross the blood-brain barrier are peripherally restricted and distribute poorly to the central nervous system after systemic administration. Peripherally... |
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Peripheral kappa-opioid agonist, ICI 204448, evokes hypothermia in cold-exposed rats.
Pharmacology 74(2) , 79-83, (2005) ICI 204448, a selective kappa-opioid agonist with limited CNS access, can be used to discriminate central and peripheral opioid actions on physiological systems such as pain and thermoregulation. Ther... |
| MFCD00153814 |
| ICI 204,448 hydrochloride |