Fosinopril-d5 sodium

Modify Date: 2024-01-10 13:16:20

Fosinopril-d5 sodium structure	Common Name	Fosinopril-d5 sodium
	CAS Number	1217513-43-3	Molecular Weight	590.68
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₄₁D₅NNaO₇P	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Fosinopril-d5 sodium

Fosinopril-d5 sodium (SQ28555-d5 sodium) is the deuterium labeled Fosinopril sodium. Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure[1][2].

Name	Fosinopril-d5 sodium

Description	Fosinopril-d5 sodium (SQ28555-d5 sodium) is the deuterium labeled Fosinopril sodium. Fosinopril Sodium is the ester prodrug of an angiotensin-converting enzyme (ACE) inhibitor, used for the treatment of hypertension and some types of chronic heart failure[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Ondetti, M.A., Structural relationships of angiotensin converting-enzyme inhibitors to pharmacologic activity. Circulation, 1988. 77(6 Pt 2): p. I74-8. [3]. Piepho, R.W., Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm, 2000. 57 Suppl 1: p. S3-7. [4]. Sharma, S., et al., The hemodynamic effects of long-term ACE inhibition with fosinopril in patients with heart failure. Fosinopril Hemodynamics Study Group. Am J Ther, 1999. 6(4): p. 181-9.

Molecular Formula	C₃₀H₄₁D₅NNaO₇P
Molecular Weight	590.68

Fosinopril-d5 sodium

Use of Fosinopril-d5 sodium

Names

Fosinopril-d5 sodium Biological Activity

Chemical & Physical Properties