Zolmitriptan-d6

Modify Date: 2024-01-09 19:39:08

Zolmitriptan-d6 structure	Common Name	Zolmitriptan-d6
	CAS Number	1217644-84-2	Molecular Weight	293.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₅D₆N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Zolmitriptan-d6

Zolmitriptan-d6 is deuterium labeled Zolmitriptan. Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].

Name	(5R)-5-[[3-[2-[bis(trideuteriomethyl)amino]ethyl]-1H-indol-5-yl]methyl]-1,3-oxazolidin-2-one
Synonym	More Synonyms

Description	Zolmitriptan-d6 is deuterium labeled Zolmitriptan. Zolmitriptan (BW-311C90; 311C90) is a 5-HT1B/1D receptor partial agonist with Kis of 5.01 nM, 0.63 nM, and 63.09 nM for 5-HT1B, 5-HT1D, 5-HT1F receptor, respectively. Zolmitriptan can be used for the research of migraine[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. G R Martin, et al. Receptor specificity and trigemino-vascular inhibitory actions of a novel 5-HT1B/1D receptor partial agonist, 311C90 (zolmitriptan). Br J Pharmacol. 1997 May;121(2):157-64. [3]. Katherine C Murray, et al. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011 Aug;106(2):925-43.

Molecular Formula	C₁₆H₁₅D₆N₃O₂
Molecular Weight	293.39
Exact Mass	293.20100
PSA	60.85000
LogP	1.56290

[2H6]-Zolmitriptan

Zolmitriptan-d6

Use of Zolmitriptan-d6

Names

Zolmitriptan-d6 Biological Activity

Chemical & Physical Properties

Synonyms