Xylometazoline hydrochloride structure
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Common Name | Xylometazoline hydrochloride | ||
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CAS Number | 1218-35-5 | Molecular Weight | 280.836 | |
Density | N/A | Boiling Point | 394.2ºC at 760 mmHg | |
Molecular Formula | C16H25ClN2 | Melting Point | 131-133ºC | |
MSDS | Chinese USA | Flash Point | 192.2ºC | |
Symbol |
GHS06 |
Signal Word | Danger |
Use of Xylometazoline hydrochlorideXylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.Target: α-AdrenoceptorXylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time [1]. Xylometazoline exhibited in radioligand competition studies higher affinities than the catecholamines adrenaline and noradrenaline at most α-adrenoceptor subtypes. Xylometazoline behaved at α(2B) -adrenoceptors as full agonists [2]. |
Name | Xylometazoline hydrochloride |
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Synonym | More Synonyms |
Description | Xylometazoline Hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant.Target: α-AdrenoceptorXylometazoline is a nasal decongestant spray that constricts nasal blood vessels and increases nasal airflow, enabling patients with a blocked nose to breathe more easily. Xylometazoline is an effective and well-tolerated decongestant nasal spray that significantly relieved nasal congestion compared with placebo in the common cold and provided long-lasting relief with just 1 spray, helping patients to breathe more easily for a longer period of time [1]. Xylometazoline exhibited in radioligand competition studies higher affinities than the catecholamines adrenaline and noradrenaline at most α-adrenoceptor subtypes. Xylometazoline behaved at α(2B) -adrenoceptors as full agonists [2]. |
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Related Catalog | |
References |
Boiling Point | 394.2ºC at 760 mmHg |
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Melting Point | 131-133ºC |
Molecular Formula | C16H25ClN2 |
Molecular Weight | 280.836 |
Flash Point | 192.2ºC |
Exact Mass | 280.170624 |
PSA | 24.39000 |
LogP | 3.71150 |
Vapour Pressure | 4.56E-06mmHg at 25°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301 |
Precautionary Statements | P301 + P310 |
Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
Hazard Codes | Xn:Harmful; |
Risk Phrases | R22 |
Safety Phrases | S36 |
RIDADR | UN 2811 6.1/PG 3 |
WGK Germany | 3 |
RTECS | NJ2390000 |
[Nasal decongestants and eye drops: keep out of children's reach!].
Perspect. Infirm. 10(2) , 63, (2013)
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Intranasal topical local anesthetic and decongestant for flexible nasendoscopy in children: a randomized, double-blind, placebo-controlled trial.
JAMA Otolaryngol. Head Neck Surg. 139(12) , 1301-5, (2013) To our knowledge, the present study is the first double-blind, randomized, placebo-controlled trial in children to compare nasal preparation sprays administered before flexible nasendoscopy with place... |
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Prognostic value of anterior rhinomanometry in diode laser turbinoplasty.
Arch. Otolaryngol. Head Neck Surg. 136(10) , 1015-9, (2010) To identify objective criteria predicting the success of diode laser-assisted turbinoplasty.Prospective before-and-after trial with follow-up of 8 weeks.Outpatient department of a tertiary referral ce... |
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MFCD00238707 |
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EINECS 214-936-4 |
Xylometazoline (hydrochloride) |