xylometazoline

Modify Date: 2024-01-06 17:35:58

xylometazoline structure	Common Name	xylometazoline
	CAS Number	526-36-3	Molecular Weight	244.38
	Density	1g/cm3	Boiling Point	394.2ºC at 760mmHg
	Molecular Formula	C₁₆H₂₄N₂	Melting Point	N/A
	MSDS	N/A	Flash Point	192.2ºC

Use of xylometazoline

Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline can be used in nose stuffiness and runny nose research[1][2].

Name	2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
Synonym	More Synonyms

Description	Xylometazoline is an α-adrenergic receptor agonist (Ki=0.05-1.7 μM). Xylometazoline can constrict nasal blood vessels and increase nasal airflow. Xylometazoline can be used in nose stuffiness and runny nose research[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Inflammation/Immunology
Target	Alpha-1A adrenergic receptor:0.05 μM (Ki) Alpha-1B adrenergic receptor:0.30 μM (Ki) Alpha-1D adrenergic receptor:0.15 μM (Ki) Alpha-2A adrenergic receptor:0.88 μM (Ki) Alpha-2B adrenergic receptor:1.7 μM (Ki) Alpha-2C adrenergic receptor:0.19 μM (Ki)
References	[1]. Ronald Eccles, et al. The nasal decongestant effect of xylometazoline in the common cold. Am J Rhinol. 2008 Sep-Oct;22(5):491-6. [2]. Britta Haenisch, et al. Alpha-adrenoceptor agonistic activity of oxymetazoline and xylometazoline. Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.

Density	1g/cm3
Boiling Point	394.2ºC at 760mmHg
Molecular Formula	C₁₆H₂₄N₂
Molecular Weight	244.38
Flash Point	192.2ºC
Exact Mass	244.19400
PSA	24.39000
LogP	2.90950
Storage condition	-20°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ2380000

CHEMICAL NAME :: 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-

CAS REGISTRY NUMBER :: 526-36-3

BEILSTEIN REFERENCE NO. :: 0180524

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C16-H24-N2

MOLECULAR WEIGHT :: 244.42

WISWESSER LINE NOTATION :: T5M CN BUTJ B1R B1 F1 DX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 215 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 46 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 29,729,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 63 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,971,1962

HS Code	2933290090

2,6-DIMETHYL-4-...

CAS#:84803-57-6

1,2-Ethanediamine

CAS#:107-15-3

xylometazoline

CAS#:526-36-3

Literature: CIBA Patent: US2868802 , 1957 ;

HS Code	2933290090
Summary	2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Novorin

2-(4-tert-Butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazol

2-(4-tert-butyl-2,6-dimethyl-benzyl)-4,5-dihydro-1H-imidazole

Xylomethazoline

Otriven

Otrix

Xilometazolina

UNII-WPY40FTH8K

2-[(4-t-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole

Otrivin

2-[(2,6-dimethyl-4-tert-butylphenyl)methyl]-4,5-dihydro-1H-imidazole

Xylometazoline

Xylometazolinum

2-(3,4-DIMETHOXY-PHENYL)-BENZO[D]IMIDAZO[2,1-B]-THIAZOLE-3-CARBALDEHYDE

Otrivine

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: xylometazoline
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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