Anthracene-9-carboxylic acid-d9

Modify Date: 2024-01-28 17:35:54

Anthracene-9-carboxylic acid-d9 Structure
Anthracene-9-carboxylic acid-d9 structure
Common Name Anthracene-9-carboxylic acid-d9
CAS Number 1219803-78-7 Molecular Weight 222.239
Density 1.3±0.1 g/cm3 Boiling Point 467.5±14.0 °C at 760 mmHg
Molecular Formula C15H10O2 Melting Point N/A
MSDS N/A Flash Point 206.1±14.8 °C

 Use of Anthracene-9-carboxylic acid-d9


Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

 Names

Name 9-Anthracenecarboxylic acid
Synonym More Synonyms

 Anthracene-9-carboxylic acid-d9 Biological Activity

Description Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13.  

[3]. Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan138(1):31-8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 467.5±14.0 °C at 760 mmHg
Molecular Formula C15H10O2
Molecular Weight 222.239
Flash Point 206.1±14.8 °C
Exact Mass 222.068085
LogP 4.36
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.743

 Synonyms

anthracene-9-carboxylic acid
9-Anthracene carboxylic acid
9-Anthracenecarboxylic acid