1219803-78-7

1219803-78-7 structure

Name: Anthracene-9-carboxylic acid-d9
Chemical Name: 9-Anthracenecarboxylic acid
CAS Number: 1219803-78-7
Molecular Formula: C₁₅H₁₀O₂
Molecular Weight: 222.239
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Chloride Channel
Create Date: 2018-04-14 23:59:58
Modify Date: 2024-01-28 17:35:54
Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].

Name	9-Anthracenecarboxylic acid
Synonyms	anthracene-9-carboxylic acid 9-Anthracene carboxylic acid 9-Anthracenecarboxylic acid

Description	Anthracene-9-carboxylic acid-d9 is the deuterium labeled Anthracene-9-carboxylic acid[1]. Anthracene-9-carboxylic acid (9-Anthracenecarboxylic acid) is an anthracene derivative traditionally used to block and identify Ca2+-activated Cl- currents (CaCCs) in various cell types, like diverse smooth muscle cells, epithelial cells and salivary gland cells[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Chloride Channel Research Areas >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Cherian OL, Menini A, Boccaccio A. Multiple effects of anthracene-9-carboxylic acid on the TMEM16B/anoctamin2 calcium-activated chloride channel. Biochim Biophys Acta. 2015 Apr;1848(4):1005-13. [3]. Piper AS, Greenwood IA. Anomalous effect of anthracene-9-carboxylic acid on calcium-activated chloride currents in rabbit pulmonary artery smooth muscle cells. Br J Pharmacol. 2003 Jan138(1):31-8.