DS-7423
Modify Date: 2024-01-11 16:46:33
DS-7423 structure
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Common Name | DS-7423 | ||
|---|---|---|---|---|
| CAS Number | 1222104-37-1 | Molecular Weight | 520.52 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H27F3N10O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DS-7423DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued |
| Name | DS-7423 |
|---|
| Description | DS-7423 is a novel potent, small-molecule dual inhibitor of PI3K/mTOR with IC50 of 15.6, 1143, 249, 262 and 34.9 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR respectively; exerts anti-tumor effect against a panel of nine OCCA cell lines with IC50 of <75 nM, regardless of the mutational status of PIK3CA; suppresses the tumor growth of OCCA in a dose-dependent manner in mouse xenograft models. Solid Tumors Phase 1 Discontinued |
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| References | References 1. Koul D, et al. Oncotarget. 2017 Mar 28;8(13):21741-21753. 2. Kashiyama T, et al. PLoS One. 2014 Feb 4;9(2):e87220. View Related Products by Target PI3K Solid Tumors |
| Molecular Formula | C22H27F3N10O2 |
|---|---|
| Molecular Weight | 520.52 |