Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt

Modify Date: 2024-01-08 19:43:41

Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt structure	Common Name	Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt
	CAS Number	122341-40-6	Molecular Weight	3000.40000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₃₄H₂₀₇N₄₁O₃₆S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Neuropeptide Y (13-36) (human, rat) trifluoroacetate salt

Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.

Name	neuropeptide y (13-36), human, rat
Synonym	More Synonyms

Description	Neuropeptide Y (13-36), amide, human is a neuropeptide Y receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor Peptides Research Areas >> Neurological Disease
Target	Neuropeptide Y receptor[1]
In Vivo	Intraventricular injections of the Y2 neuropeptide Y receptor agonist porcine Neuropeptide Y (13-36) (25-3000 pM) produces a dose-dependent increase (up to 14%; ED50=0.3 nM for overall effects and 0.97 nM for the peak effects) in mean arterial blood pressure in the awake, unrestrains male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat[1].
Animal Admin	Rats[1] Neuropeptide Y (13-36) dissolved in 30 μL mock cerebrospinal fluid (CSF), or CSF alone, is injected (30/μL/3 min) by means of an automatic micro-injection pump into the lateral ventricle of freely moving, unrestrained male rats. Five doses of Neuropeptide Y (13-36) (25, 75, 750, 1250, 3000 pM) are injected in order to evaluate possible dose-dependent effects and the effects are compared with the CSF group. A threshold dose of Neuropeptide Y (13-36) is also injected together with a dose of Neuropeptide Y (1-36) (75 pM), close to the ED50 value for its overall vasodepressor action in awake rats[1].
References	[1]. Aguirre JA, et al. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett. 1990 Oct 2;118(1):5-8.

Molecular Formula	C₁₃₄H₂₀₇N₄₁O₃₆S
Molecular Weight	3000.40000
Exact Mass	2998.53000
PSA	1308.16000
LogP	5.22100

L-Pro-L-Ala-L-Glu-L-Asp-L-Met-L-Ala-L-Arg-L-Tyr-L-Tyr-L-Ser-L-Ala-L-Leu-L-Arg-L-His-L-Tyr-L-Ile-L-Asp(NH2)-L-Leu-L-Ile-L-Thr-L-Arg-L-Gln-L-Arg-L-Tyr-NH2

NPY (13-36) (HUMAN,RAT)

PAEDMARYYSALRHYINLITRQRY-NH2

NEUROPEPTIDE Y (13-36) HUMAN

PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

REF DUPL: H-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2

H-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2

Neuropeptide Y (13-36), amide, human