Tyrphostin AG 30

Modify Date: 2024-01-16 17:43:32

Tyrphostin AG 30 Structure
Tyrphostin AG 30 structure
 Common Name Tyrphostin AG 30
CAS Number 122520-79-0 Molecular Weight 205.16700
Density 1.559g/cm3 Boiling Point 465.6ºC at 760mmHg
Molecular Formula C10H7NO4 Melting Point N/A
MSDS N/A Flash Point 235.4ºC

 Use of Tyrphostin AG 30


Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].

 Names

Name (E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid
Synonym More Synonyms

 Tyrphostin AG 30 Biological Activity

Description Tyrphostin AG30 (AG30) is a potent protein tyrosine kinases (PTK) inhibitor. Tyrphostin AG30 (AG30) selectively inhibits self renewal induction by c-ErbB, and is able to inhibit activation of STAT5 by c-ErbB in primary erythroblasts[1][2].
Related Catalog
References

[1]. Volberg T, et al. The effect of tyrosine-specific protein phosphorylation on the assembly of adherens-type junctions. EMBO J. 1992 May;11(5):1733-42.

[2]. Wessely O, et al. Distinct roles of the receptor tyrosine kinases c-ErbB and c-Kit in regulating the balance between erythroid cell proliferation and differentiation. Cell Growth Differ. 1997 May;8(5):481-93.

 Chemical & Physical Properties

Density 1.559g/cm3
Boiling Point 465.6ºC at 760mmHg
Molecular Formula C10H7NO4
Molecular Weight 205.16700
Flash Point 235.4ºC
Exact Mass 205.03800
PSA 101.55000
LogP 1.08938
Vapour Pressure 1.8E-09mmHg at 25°C
Index of Refraction 1.717

 Safety Information

Hazard Codes Xi

 Synonyms

3.4-Dioxy-benzylidencyanessigsaeure
2-cyano-3-(3,4-dihydroxy-phenyl)-acrylic acid
(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylic acid
AG 30
2-Propenoic acid,2-cyano-3-(3,4-dihydroxyphenyl)-,(E)
Tyrphostin AG 30
(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-2-propenoic acid
Tyrophostin AG 30
2-Cyan-3-(3,4-dihydroxy-phenyl)-acrylsaeure
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