AZD3839

Modify Date: 2024-02-04 09:58:50

AZD3839 Structure
AZD3839 structure
Common Name AZD3839
CAS Number 1227163-56-5 Molecular Weight 449.40
Density N/A Boiling Point N/A
Molecular Formula C24H15F4N5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of AZD3839


(Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease[1].

 Names

Name 4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
Synonym More Synonyms

 AZD3839 Biological Activity

Description (Rac)-AZD3839 is an orally active beta-amyloid precursor protein cleaving enzyme (BACE1) inhibitor that is blood-brain barrier-permeable. (Rac)-AZD3839 has an affinity for the human ether-a-go-go related gene (hERG) ion channel. (Rac)-AZD3839 can be used in the research of Alzheimer's disease[1].
Related Catalog
References

[1]. Britt-Marie Swahn, et, al. Design and synthesis of β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors with in vivo brain reduction of β-amyloid peptides. J Med Chem2012, 55, 21.  

 Chemical & Physical Properties

Molecular Formula C24H15F4N5
Molecular Weight 449.40
Exact Mass 449.12600
PSA 77.05000
LogP 4.84320
Storage condition -20℃

 Synonyms

4-Fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1-(2-(trifluoromethyl)pyridin-4-yl)-1H-isoindol-3-amine
AZD3839