AZD3839
Modify Date: 2024-01-17 11:12:59
AZD3839 structure
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Common Name | AZD3839 | ||
|---|---|---|---|---|
| CAS Number | 1227163-84-9 | Molecular Weight | 431.413 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 596.3±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H16F3N5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 314.4±32.9 °C | |
Use of AZD3839AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.target: BACE1, β-secretase enzyme [1]IC50: 23.6 uM [1]AZD3839 dissolved in 0.33% dimethylsulfoxideIn vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1]In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2] |
| Name | azd-3839 |
|---|---|
| Synonym | More Synonyms |
| Description | AZD3839 (free base) is a potent and selective BACE1 inhibitor with IC50 of 23.6 uM, about 14-fold selectivity over BACE2, also a β-secretase enzyme inhibitor.target: BACE1, β-secretase enzyme [1]IC50: 23.6 uM [1]AZD3839 dissolved in 0.33% dimethylsulfoxideIn vitro: AZD3839 and its metabolites M1 and M2 inhibited CYP3A4 in a reversible and an irreversible manner, which could affect not only the metabolism of other CYP3A4 substrates but also the metabolism of AZD3839 itself. [1]In vivo: AZD3839 is dissolved in 0.3 M gluconic acid, adjusted to pH 3. Solutions of 0.75, 2.5, and 7.5 mg/ml are prepared and are administered orally by gavage at 2 ml/kg body weight at 1.5, 5, and 15 mg/kg (study 1) and 15 mg/kg (study 2). [1]AZD3839 effectively reduces the levels of Aβ in brain, CSF, and plasma in several preclinical species. [2] |
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| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 596.3±60.0 °C at 760 mmHg |
| Molecular Formula | C24H16F3N5 |
| Molecular Weight | 431.413 |
| Flash Point | 314.4±32.9 °C |
| Exact Mass | 431.135773 |
| PSA | 77.05000 |
| LogP | 1.35 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.674 |
| Storage condition | -20℃ |
| 1H-Isoindol-3-amine, 1-[2-(difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-, (1S)- |
| (1S)-1-(2-(Difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine |
| AZD3839 |
| (S)-1-(2-(difluoromethyl)pyridin-4-yl)-4-fluoro-1-(3-(pyrimidin-5-yl)phenyl)-1H-isoindol-3-amine |
| 1H-Isoindol-3-amine, 1-(2-(difluoromethyl)-4-pyridinyl)-4-fluoro-1-(3-(5-pyrimidinyl)phenyl)-, (1S)- |
| (1S)-1-[2-(Difluoromethyl)-4-pyridinyl]-4-fluoro-1-[3-(5-pyrimidinyl)phenyl]-1H-isoindol-3-amine |
| AZD 3839 |
| AZD3839 (free base) |