Philanthotoxin 74
Modify Date: 2024-01-16 12:10:23
Philanthotoxin 74 structure
|
Common Name | Philanthotoxin 74 | ||
|---|---|---|---|---|
| CAS Number | 1227301-51-0 | Molecular Weight | 507.537 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C24H44Cl2N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Philanthotoxin 74Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. |
| Name | N-{7-[(4-Aminobutyl)amino]heptyl}-Nα-butyryltyrosinamide dihydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Philanthotoxin 74 dihydrochloride (PhTx 74) is an AMPAR antagonist; inhibits GluR3 and GluR1 with IC50s of 263 and 296 nM, respectively. |
|---|---|
| Related Catalog | |
| Target |
IC50: 296 nM (GluR1), 296 nM (GluR1)[1] Ki: 0.29 μM (GluR5Q)[2] |
| In Vitro | Philanthotoxin 74 in the micromolar concentration range displays selective inhibition between the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 is reported to fully inhibit GluA1/A2R receptors when applied at a concentration of 500 μM while producing 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74, when tested at concentrations of 100 and 500 μM, displays pronounced channel block (more than 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Oocytes expressing GluA2R alone that homomeric GluA2R is virtually inert to philanthotoxin 74 in the 0.1-300 μM concentration range, displaying less than 5% inhibition at the maximum tested concentration of 300 μM. Philanthotoxin 74 inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1]. |
| References |
| Molecular Formula | C24H44Cl2N4O3 |
|---|---|
| Molecular Weight | 507.537 |
| Exact Mass | 506.279053 |
| Storage condition | 2-8℃ |
| N-{7-[(4-Aminobutyl)amino]heptyl}-Nα-butyryltyrosinamide dihydrochloride |
| Benzenepropanamide, N-[7-[(4-aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]-, (αS)-, hydrochloride (1:2) |
| Philanthotoxin 74 dihydrochloride |