XE 991 dihydrochloride

Modify Date: 2024-01-05 23:17:16

XE 991 dihydrochloride structure	Common Name	XE 991 dihydrochloride
	CAS Number	122955-13-9	Molecular Weight	449.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₆H₂₂Cl₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of XE 991 dihydrochloride

XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].

Name	XE 991 (hydrochloride)
Synonym	More Synonyms

Description	XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1]
In Vitro	XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2].
References	[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.

Molecular Formula	C₂₆H₂₂Cl₂N₂O
Molecular Weight	449.37
Exact Mass	448.110931
PSA	42.85000
LogP	6.39650
Storage condition	-20°C

9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-, hydrochloride (1:2)

10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride

NPE-caged-HPTS

10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: XE 991 dihydrochloride
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: XE 991 dihydrochloride
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: XE 991 dihydrochloride
Price: $500.0/100mg $850.0/250mg $1700.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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