122955-13-9

122955-13-9 structure

Name: XE 991 dihydrochloride
Chemical Name: XE 991 (hydrochloride)
CAS Number: 122955-13-9
Molecular Formula: C₂₆H₂₂Cl₂N₂O
Molecular Weight: 449.37
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2016-08-03 07:05:22
Modify Date: 2024-01-05 23:17:16
XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].

Name	XE 991 (hydrochloride)
Synonyms	9(10H)-Anthracenone, 10,10-bis(4-pyridinylmethyl)-, hydrochloride (1:2) 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one dihydrochloride NPE-caged-HPTS 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone dihydrochloride

Description	XE 991 dihydrochloride, a Kv7 (KCNQ) channels blocker, potently inhibits Kv7.1 (KCNQ1), Kv7.2 (KCNQ2), Kv7.2 + Kv7.3 (KCNQ3) channel, and M-current with IC50s of 0.75 µM, 0.71 µM, 0.6 μM, and 0.98 µM, respectively[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 0.75 µM ( Kv7.1 channel), 0.71 µM (Kv7.2 channel), 0.6 µM (Kv7.2 + Kv7.3 channel), 0.98 μM (M-current)[1]
In Vitro	XE 991 dihydrochloride possesses an EC50 of 490 nM for enhancement of [3H]ACh release from rat brain slices, and shows good in vivo potency and duration of action[2].
References	[1]. Wang HS, et al. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. [2]. Zaczek R, et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther. 1998 May;285(2):724-30.