Tenapanor hydrochloride
Modify Date: 2024-01-02 10:36:08
Tenapanor hydrochloride structure
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Common Name | Tenapanor hydrochloride | ||
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| CAS Number | 1234365-97-9 | Molecular Weight | 1217.970 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C50H68Cl6N8O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Tenapanor hydrochlorideTenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia[1][2]. |
| Name | tenapanor hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Tenapanor (AZD1722) hydrochloride is a potent and orally active sodium/hydrogen exchanger isoform 3 (NHE3) inhibitor. Tenapanor hydrochloride reduces intestinal phosphate absorption predominantly through reduction of passive paracellular phosphate flux. Tenapanor hydrochloride has the potential for the research of hyperphosphatemia[1][2]. |
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| Related Catalog | |
| In Vivo | Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats[1]. Tenapanor hydrochloride (0.15 mg/kg; p.o.; twice-daily for 11 consecutive days) increases the reduction in urinary phosphorus excretion in rats[2]. Animal Model: Rats (intestinal loop model)[1] Dosage: 0.15, 0.5 mg/kg Administration: P.o. Result: Reduced passive paracellular phosphate absorption by reduced urinary phosphate and sodium excretion after the high-phosphate meal and increased sodium and phosphate delivery to the cecum. Animal Model: 8 weeks, 250 g male Sprague–Dawley rats[2] Dosage: 0.15 mg/kg in combination with sevelamer (0%, 0.75%, 1.5%, and 3% (wt/wt)) Administration: Oral gavage; twice-daily for 11 consecutive days Result: Significantly augmented the reduction in urinary phosphorus excretion. |
| References |
| Molecular Formula | C50H68Cl6N8O10S2 |
|---|---|
| Molecular Weight | 1217.970 |
| Exact Mass | 1214.263062 |
| tenapanor HCl |
| N,N'-(10,17-Dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis{3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydro-4-isoquinolinyl]benzenesulfonamide} dihydrochloride |
| tenapanor hydrochloride |
| 50605O2ZNS |
| RDX5791 |
| AZD1722 hydrochloride |
| 1,1'-(butane-1,4-diyl)bis{3-[2-(2-{2-[({3-[(4S)-6,8-dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl]phenyl}sulfonyl)amino]ethoxy}ethoxy)ethyl]urea} dihydrochloride |
| Benzenesulfonamide, N,N'-(10,17-dioxo-3,6,21,24-tetraoxa-9,11,16,18-tetraazahexacosane-1,26-diyl)bis[3-[(4S)-6,8-dichloro-1,2,3,4-tetrahydro-2-methyl-4-isoquinolinyl]-, hydrochloride (1:2) |