740 Y-P

Modify Date: 2024-01-08 18:50:40

740 Y-P structure	Common Name	740 Y-P
	CAS Number	1236188-16-1	Molecular Weight	3270.7
	Density	1.5±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄₁H₂₂₂N₄₃O₃₉PS₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 740 Y-P

740 Y-P (PDGFR 740Y-P) is a potent and cell permeable PI3K activator.

Name	740 Y-P

Description	740 Y-P (PDGFR 740Y-P) is a potent and cell permeable PI3K activator.
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Research Areas >> Cancer Peptides Peptides
Target	PI3K
In Vitro	740 Y-P is a synthetic biotinylated peptide consisting of the 16-amino acid sequence derived from the third helix of the Antennapedia protein in tandem with a 9 amino acid phosphopeptide mimetic of the high affinity p85 binding site on the PDGF receptor. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85. 740 Y-P fails to bind GST alone, or a GST fusion protein containing the N- terminal SH2 domain of PLCg and shows relatively weak binding of a GST fusion proteins containing the SH2 domain of Grb2. The 740 Y-P peptide is also able to specifically interact with p85 in cell lysates as shown by affinity precipitation. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides[1].
In Vivo	740 Y-P is not only internalised in living cells but can also interact with p85 in vivo.[1]
Cell Assay	Following serum starvation, C2 cells are cultured in the presence of the PDGFR 740Y-P peptide at the given concentrations (0, 1, 10, 100 μg/mL) for 48 h. The mitogenic response is assessed by measurement of the percentage of cells in S-phase[1].
References	[1]. Derossi D, et al. Stimulation of mitogenesis by a cell-permeable PI 3-kinase binding peptide.

Density	1.5±0.1 g/cm3
Molecular Formula	C₁₄₁H₂₂₂N₄₃O₃₉PS₃
Molecular Weight	3270.7
Exact Mass	3268.561035
LogP	-6.32
Index of Refraction	1.679
Storage condition	-20°C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 740Y-P
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: 740 Y-P
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: 740 Y-P
Price: $1100.0/50mg $1900.0/100mg $3600.0/250mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Taiwan Oyi peptide Co. Ltd
China
Product Name: 740 Y-P
Price: $Inquiry/1mg $Inquiry/100kg
Purity: 98.0%
Delivery: 1 Day
Contact: Vinnie
Email: Jamie@api-made.com

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Price: $120/1mg

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