4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

Modify Date: 2024-01-08 17:14:34

4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt structure	Common Name	4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt
	CAS Number	124168-73-6	Molecular Weight	490.553
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₃H₃₄N₆O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of 4-Abz-Gly-Pro-D-Leu-D-Ala-NHOH trifluoroacetate salt

FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].

Name	4-Aminobenzoyl-Gly-Pro-D-Leu-D-Ala hydroxamic acid
Synonym	More Synonyms

Description	FN-439 is a selective collagenase-1 inhibitor. FN-439 inhibits collagenase-1 with an IC50 value of 1 μM. FN-439 can be used for the research of cancer and inflammation[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Inflammation/Immunology Signaling Pathways >> Metabolic Enzyme/Protease >> MMP
In Vitro	FN-439 inhibits collagenase-1 with an IC50 value of 1 μM[1]. FN-439 (1 μM) reduces the invasive potential of MDA-MB-231 breast cancer cells[1].
In Vivo	FN-439 significantly decreases neutrophils and macrophages, shows extensive bone formation and active cementogenesis in the periapical region when has a combination with ofloxaci[2].

Density	1.3±0.1 g/cm3
Molecular Formula	C₂₃H₃₄N₆O₆
Molecular Weight	490.553
Exact Mass	490.253998
PSA	182.96000
LogP	-0.69
Index of Refraction	1.583

MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Impaired Focal Adhesion Kinase-Grb2 Interaction during Elevated Activity in Hippocampal Neurons.

Int. J. Mol. Sci. 16 , 15659-69, (2015)

Excitatory/inhibitory imbalances are implicated in many neurological disorders. Previously, we showed that chronically elevated network activity induces vulnerability in neurons due to loss of signal ...

Inhibition of matrix metalloproteinases by peptidyl hydroxamic acids.

Biochem. Biophys. Res. Commun. 199 , 1442-6, (1994)

Synthetic inhibitors of interstitial collagenase, tri- and tetrapeptidyl hydroxamic acids, have been developed and tested for their inhibitory activities against human matrix metalloproteinases. A wat...

Vertebrate collagenase inhibitor. II. Tetrapeptidyl hydroxamic acids.

Chem. Pharm. Bull. Tokyo 39 , 1489-1494, (1991)

To develop a potent and specific collagenase inhibitor, a series of tetrapeptidyl hydroxamic acids were synthesized, based on the previous findings with tripeptidyl derivatives (Chem. Pharm. Bull., 38...

D-Alaninamide, N-(4-aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-

1-[2-[(4-aminobenzoyl)amino]acetyl]-N-[1-[[1-(hydroxyamino)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide

MFCD00237459

N-(4-Aminobenzoyl)glycyl-L-prolyl-D-leucyl-N-hydroxy-D-alaninamide