Omaciclovir

Modify Date: 2024-01-09 00:38:43

Omaciclovir Structure
Omaciclovir structure
Common Name Omaciclovir
CAS Number 124265-89-0 Molecular Weight 253.25800
Density 1.68g/cm3 Boiling Point 637.8ºC at 760 mmHg
Molecular Formula C10H15N5O3 Melting Point N/A
MSDS N/A Flash Point 339.5ºC

 Use of Omaciclovir


Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity[1].

 Names

Name 2-amino-9-[(2R)-4-hydroxy-2-(hydroxymethyl)butyl]-3H-purin-6-one
Synonym More Synonyms

 Omaciclovir Biological Activity

Description Omaciclovir (H2G) is a potent and selective inhibitor of herpesvirus replication. Omaciclovir is a nucleoside analog with antiviral activity[1].
Related Catalog
In Vitro Omaciclovir is a nucleoside analog with in vitro inhibitory activity against varicella-zoster virus (VZV), herpes simplex virus types 1 and 2 (HSV-1 and -2), Epstein-Barr virus, and human herpesvirus 6. Omaciclovir is also efficacious in simian varicella virus-infected monkeys[1]. Omaciclovir shows antiviral activities against different human herpesviruses with EC50s of 0.72 ± 0.1, 0.62 ± 0.2, 0.015 ± 0.004, 0.048 ± 0.023, 0.047 ± 0.004, 0.035 ± 0.022, and 0.016 ± 0.003 μM for MRC-5 VZV-32, MRC-5 Molly, MeWo VZV-32, MeWo Molly, MeWo Emily, MeWo VZ11, and MeWo VZ30, respectively[1].
References

[1]. T I Ng , et al. Selection and Characterization of Varicella-Zoster Virus Variants Resistant to (R)-9-[4-hydroxy-2-(hydroxymethy)butyl]guanine. Antimicrob Agents Chemother. 2001 Jun;45(6):1629-36.

 Chemical & Physical Properties

Density 1.68g/cm3
Boiling Point 637.8ºC at 760 mmHg
Molecular Formula C10H15N5O3
Molecular Weight 253.25800
Flash Point 339.5ºC
Exact Mass 253.11700
PSA 131.04000
Vapour Pressure 3.85E-17mmHg at 25°C
Index of Refraction 1.748

 Synonyms

H2G
Omaciclovir
2-HMHBG
Omaciclovir (USAN/INN)
ABT-091
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