GNF-6231
Modify Date: 2024-01-03 15:02:27
GNF-6231 structure
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Common Name | GNF-6231 | ||
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| CAS Number | 1243245-18-2 | Molecular Weight | 448.493 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 746.0±60.0 °C at 760 mmHg | |
| Molecular Formula | C24H25FN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 405.0±32.9 °C | |
Use of GNF-6231GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy. |
| Name | GNF-6231 |
|---|---|
| Synonym | More Synonyms |
| Description | GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.1) GNF-6231 shows IC50s of greater than 10 μM on all CYP isoforms tested2) GNF-6231 have favorable potency and a PK profile across preclinical species upon oral administration.3) The reference for orally in MMTV-Wnt1 tumor bearing mice is dosed at 3 mg/kg.4) GNF-6231 showed very robust dose-related antitumor efficacy. |
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| Related Catalog | |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 746.0±60.0 °C at 760 mmHg |
| Molecular Formula | C24H25FN6O2 |
| Molecular Weight | 448.493 |
| Flash Point | 405.0±32.9 °C |
| Exact Mass | 448.202301 |
| LogP | 0.79 |
| Vapour Pressure | 0.0±2.5 mmHg at 25°C |
| Index of Refraction | 1.627 |
| Storage condition | -20℃ |
| N-[5-(4-Acetyl-1-piperazinyl)-2-pyridinyl]-2-(2'-fluoro-3-methyl-2,4'-bipyridin-5-yl)acetamide |
| [2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl- |